Functional changes in the gut microbiota are associated with the intestinal phenotype in A20 haploinsufficiency.

doi:10.1111/pai.70343

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Functional changes in the gut microbiota are associated with the intestinal phenotype in A20 haploinsufficiency.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Apr 2026

Elhani Inès, Bredon Marius, Enea Diana, Desmons Aurore, Arrive Lionel, Bazille Céline, Lefevre Antoine, Aouba Achille, Bigot Adrien, de Moreuil Claire, Alonso Iria, Blasco Hélène, Creusot Laura, Dupuy Camille, Emond Patrick, Krasniqi Pranvera, Lamaziere Antonin, Oeuvray Cyriane, Rainteau Dominique, Svrcek Magali, Rolhion Nathalie, Sokol Harry, Georgin-Lavialle Sophie

Abstract excerpt

BACKGROUND: A20 haploinsufficiency (HA20) is an autoinflammatory disease driven by pathogenic variants in TNFAIP3, which plays a crucial role in regulating immune responses. The clinical manifestations of HA20 resemble those of inflammatory bowel disease (IBD), with prominent gastrointestinal (GI) involvement. Given the well-established association between gut microbiota alterations and IBD, this study aimed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feces

Share to Gastrointestinal Microbiome

Share to Haploinsufficiency

Share to Inflammatory Bowel Diseases

Share to Intestines

Share to Liver Diseases

Share to Tumor Necrosis Factor alpha-Induced Protein 3

Source

Open in PubMed Open full text

Identifiers

PMID: 41991504
DOI: 10.1111/pai.70343
PMCID: PMC13086603

Genes

TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional changes in the gut microbiota are associated with the intestinal phenotype in A20 haploinsufficiency.PMID 41991504Read ↗

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in severe COVID-19Semantic proximity Read ↗

Deciphering the microbiome–metabolome landscape of an inflammatory bowel disease inception cohortSemantic proximity Read ↗

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatmentSemantic proximity Read ↗

Mucosal Metabolomic Signatures in Chronic Colitis: Novel Insights into the Pathophysiology of Inflammatory Bowel DiseaseSemantic proximity Read ↗

Bugs, genes, fatty acids, and serotonin: Unraveling inflammatory bowel disease?Semantic proximity Read ↗

Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Semantic proximity Read ↗

The human gut microbiota and uric acid metabolism: genes, metabolites, and dietSemantic proximity Read ↗

Impact of Microbial Dysbiosis and Tryptophan Metabolites in Advanced Stages of Colorectal CancerSemantic proximity Read ↗

Fecal Microbial and Metabolic Signatures in VEO-IBD: Implications for Unique PathophysiologySemantic proximity Read ↗

The role of intestine in metabolic dysregulation in murine Wilson diseaseSemantic proximity Read ↗

From Mutations to Microbes: Investigating the Impact of the Gut Microbiome on Repeat Expansion Disorders.Semantic proximity Read ↗

Integrated Analysis of Microbiome and Metabolome Reveals Disease-Specific Profiles in Inflammatory Bowel Diseases and Intestinal Behçet’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.