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Article

KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity.

Genes & development - 1 Jun 2026

Hamm Danielle C, O'Donnell Aidan B, Bennett Sean R, Lemmers Richard J L F, van der Vliet Patrick J, van der Maarel Silvère M, Tapscott Stephen J

Abstract excerpt

DUX4 initiates the first wave of zygotic genome activation (ZGA) in the human embryo, and its misexpression in skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). However, other factors that help regulate ZGA-like transcription in human development and disease are still not fully understood. Here we identify Krüppel-like factor 18 (KLF18) as a component of a DUX4 feed-forward network that is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscular Dystrophy, Facioscapulohumeral

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Source

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Identifiers

PMID: 41986233
DOI: 10.1101/gad.353253.125
PMCID: PMC13224869

Genes

DUX4
KLF18
KLF17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity.PMID 41986233Read ↗

DUX4 at 25: how it emerged from “junk DNA” to become the cause of facioscapulohumeral muscular dystrophySemantic proximity Read ↗

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P38α Regulates Expression of DUX4 in Facioscapulohumeral Muscular DystrophySemantic proximity Read ↗

DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral DystrophySemantic proximity Read ↗

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