Article
Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting.
Nature genetics - 1 Apr 2026
Fejzo Marlena, Wang Xinran, Tan Qing, Zöllner Julia, Pujol-Gualdo Natàlia, Laisk Triin, Finer Sarah, van Heel David A, Brumpton Ben, Bhatta Laxmi, Hveem Kristian, Jasper Elizabeth A, Velez Edwards Digna R, Hellwege Jacklyn N, Edwards Todd, Jarvik Gail P, Luo Yuan, Khan Atlas, MacGibbon Kimber, Gao Yuan, Ge Gaoxiang, Averbukh Inna, Soon Erin, Angelo Michael, Magnus Per, Johansson Stefan, Njølstad Pål R, Kim Artem, Gazal Steven, Vaudel Marc, Shu Chang April, Mancuso Nicholas
Abstract excerpt
Most pregnancies are affected by nausea and vomiting, but the most severe form-hyperemesis gravidarum-can be life threatening. Here we performed a multi-ancestry genome-wide association study of hyperemesis gravidarum in 10,974 cases and 461,461 controls across European, Asian, African and Latino ancestries. We identified ten associations: four identified previously (GDF15, IGFBP7, PGR and GFRAL) and six...
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