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Article

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum.

Nature communications - 21 Mar 2018

Fejzo Marlena S, Sazonova Olga V, Sathirapongsasuti J Fah, Hallgrímsdóttir Ingileif B, Vacic Vladimir, MacGibbon Kimber W, Schoenberg Frederic P, Mancuso Nicholas, Slamon Dennis J, Mullin Patrick M

Abstract excerpt

Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3-2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is essential for comprehending the disease etiology. Here, we conduct a genome-wide association study (GWAS) for binary...

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Source

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Identifiers

PMID: 29563502
DOI: 10.1038/s41467-018-03258-0
PMCID: PMC5862842

Genes

GDF15
IGFBP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum.PMID 29563502Read ↗

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Whole‐exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarumSemantic proximity Read ↗

Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis GravidarumSemantic proximity Read ↗

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