Delineating white matter phenotypes of sensori-/psychomotor functioning in large-scale cohorts of healthy individuals and patients with mental disorders across the lifespan (whiteSPAN): rationale and methods of an interdisciplinary bicentric project.

Abstract excerpt

Aberrant sensori-/psychomotor functioning-including muscular hand weakness, sedentary behavior, psychomotor agitation, slowing, agitation, apathy, and anxiety-is increasingly recognized as a transdiagnostic feature across mental and neurodegenerative disorders. Objectively measured sensori-/psychomotor abnormalities serve as rapid, noninvasive indicators of cognitive and affective dysfunction, yet large-scale...

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