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Article

Characteristics and Clinical Value of MYC , BCL2, and BCL6 Rearrangement Detected by Next-generation Sequencing in DLBCL.

The American journal of surgical pathology - 1 Aug 2024

Zeng Yupeng, Wei Ran, Bao Longlong, Xue Tian, Qin Yulan, Ren Min, Bai Qianming, Yao Qianlan, Yu Chengli, Chen Chen, Wei Ping, Yu Baohua, Cao Junning, Li Xiaoqiu, Zhang Qunling, Zhou Xiaoyan

Abstract excerpt

MYC , BCL2, and BCL6 rearrangements are clinically important events of diffuse large B-cell lymphoma (DLBCL). The ability and clinical value of targeted next-generation sequencing (NGS) in the detection of these rearrangements in DLBCL have not been fully determined. We performed targeted NGS (481-gene-panel) and break-apart FISH of MYC , BCL2, and BCL6 gene regions in 233 DLBCL cases. We identified 88...

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Share to Gene Rearrangement
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Large B-Cell, Diffuse

Share to Predictive Value of Tests

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-bcl-6

Share to Proto-Oncogene Proteins c-myc

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Identifiers

PMID: 38937822
DOI: 10.1097/PAS.0000000000002258
PMCID: PMC11251499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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