Article
Desert Immune Phenotype in Endometrial Carcinoma: A Distinct Subgroup With Poor Prognosis and Targetable Mutations.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2026
Kaya Merve, Lin Lawrence H, Oosting Jan, Powell Melanie E, Davidson Emma J, Leary Alexandra, Mileshkin Linda R, Shepherd Lois, de Bruyn Marco, Jobsen Jan, Kroep Judith R, Creutzberg Carien L, Horeweg Nanda, Léon-Castillo Alicia, Parra-Herran Carlos, Smit Vincent T H B M, Nucci Marisa R, Bosse Tjalling
Abstract excerpt
Accurate assessment of the tumor immune microenvironment is increasingly important for risk stratification in endometrial carcinoma (EC). Existing immune profiling methods often rely on immunohistochemistry and digital quantification to distinguish inflamed and excluded phenotypes, whereas the Desert phenotype-marked by minimal immune infiltration-may be identifiable on routine hematoxylin and eosin (H&E) slides....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.