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Article

Low-density lipoprotein cholesterol and risk of hepatocellular carcinoma: a Mendelian randomization and mediation analysis.

Lipids in health and disease - 31 Jul 2023

Cao Jiali, Wang Ziwen, Zhu Mengpei, Huang Yumei, Jin Ze, Xiong Zhifan

Abstract excerpt

BACKGROUND: A previous study demonstrated that low-density lipoprotein cholesterol (LDL-C) is associated with hepatocellular carcinoma (HCC); however, the causality between them has not been proven due to conflicting research results and the interference of confounders. This study utilized Mendelian randomization (MR) to investigate the causal relationship between LDL-C and HCC and identify the mediating factors....

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Identifiers

PMID: 37525197
DOI: 10.1186/s12944-023-01877-1
PMCID: PMC10388495

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