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Article

Genetic variants of the transporter SLC22A4 affect the abundance and survival of Fusobacterium nucleatum in colorectal cancer.

Gut microbes - 31 Dec 2026

Chouaibi Samah, Fertitta Veronica, Porreca Silvia, Njim Leila, Carcagnì Antonella, Toietta Gabriele, Canettieri Gianluca, Zouari Khadija, Mastouri Maha, Kadri Yosr, Pani Giovambattista

Abstract excerpt

The intestinal microbiota influences colorectal cancer (CRC) development, but its interactions with the host's genetic profile during tumorigenesis are poorly understood. We quantified the CRC-associated pathobiont Fusobacterium nucleatum (F. nucleatum) and the commensal Escherichia coli (E. coli) in 99 cases of archival colorectal cancer and adjacent normal mucosa. Tissues were genotyped for the 503F variant of...

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Identifiers

PMID: 42246276
DOI: 10.1080/19490976.2026.2681818
PMCID: PMC13245087

Genes

SLC22A4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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