Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploratory evaluation of the somatic and immunologic landscape of primary and metastatic cervical cancer to better inform future clinical trial development.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Dec 2025

Cerda Victoria, Rimel Bobbie J, Mercer Jacob, Thompson Michael A, Shieh Denise, Barber Emma L, Dewdney Summer, Salani Ritu, Tergas Ana I, Tucker Katherine, Kamrava Mitchell

Abstract excerpt

OBJECTIVE: To explore the somatic and immunologic landscape of cervical primary versus metastatic tumors for differential sensitivity of metastatic cervical sites and potential therapeutic implications. METHODS: Patients with sequenced squamous cell cervical cancer were selected from the Tempus Database (2016-2023). The cohort included 136 unmatched samples (73 primary, 63 metastatic sites). Pathogenic somatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4 gene

Share to PIK3CA gene

Share to Microsatellite Instability

Share to Mutation

Share to Uterine Cervical Neoplasms

Source

Identifiers

PMID: 41138573
DOI: 10.1016/j.ijgc.2025.102677

Genes

CD4
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploratory evaluation of the somatic and immunologic landscape of primary and metastatic cervical cancer to better inform future clinical trial development.PMID 41138573Read ↗

The differences in immune features and genomic profiling between squamous cell carcinoma and adenocarcinoma - A multi-center study in Chinese patients with uterine cervical cancer.Semantic proximity Read ↗

PIK3CA mutation-induced immune microenvironment remodeling sensitizes cervical cancer to immunotherapy.Semantic proximity Read ↗

Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironmentSemantic proximity Read ↗

Multi-omic and immune landscapes of HPV-negative versus HPV-positive cervical cancer reveal implications for immunotherapy.Semantic proximity Read ↗

Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.Semantic proximity Read ↗

Assessing the Genomic Landscape of Cervical Cancers: Clinical Opportunities and Therapeutic Targets.Semantic proximity Read ↗

Tertiary lymphoid structures critical for the prognosis of patients with cervical cancerSemantic proximity Read ↗

Genomic landscape, immune characteristics and a prognostic mutation signature of cervical cancer in ChinaSemantic proximity Read ↗

Genomic profiles and their relationships with clinical characteristics and immune features in cervical cancerSemantic proximity Read ↗

Integrated genomic and molecular characterization of cervical cancer.Semantic proximity Read ↗

Decoding the tumor microenvironment and molecular mechanism: unraveling cervical cancer subpopulations and prognostic signatures through scRNA-Seq and bulk RNA-seq analysesSemantic proximity Read ↗

Genetic analysis of cervical cancer with lymph node metastasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.