Article
Genetic landscape of stage II melanoma identifies CBL as a new driver gene and prognostic biomarker.
British journal of cancer - 1 Jun 2026
Lindner Elena Sophia, Admard Jakob, Demidov German, Armeanu-Ebinger Sorin, Sinnberg Tobias, Niessner Heike, Amaral Teresa, Garbe Claus, Forschner Andrea, Kelemen Olga, Hilke Franz Joachim, Bonzheim Irina, Röcken Martin, Rieß Olaf, Ossowski Stephan, Schroeder Christopher
Abstract excerpt
BACKGROUND: While adjuvant therapies are currently recommended for patients with stage IIB-IV melanoma, biomarkers are missing to improve risk stratification to select the most efficient treatment and patients to be included in clinical trials. We genetically characterized a large cohort of patients with stage-II-melanoma to identify predictive and prognostic biomarkers. METHODS: Clinical data of 193...
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