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Article

Reconstructing the History of Variation in Effective Population Size along Phylogenies.

Genome biology and evolution - 3 Aug 2021

Brevet Mathieu, Lartillot Nicolas

Abstract excerpt

The nearly neutral theory predicts specific relations between effective population size (Ne) and patterns of divergence and polymorphism, which depend on the shape of the distribution of fitness effects (DFE) of new mutations. However, testing these relations is not straightforward, owing to the difficulty in estimating Ne. Here, we introduce an integrative framework allowing for an explicit reconstruction of the...

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Identifiers

PMID: 34190972
DOI: 10.1093/gbe/evab150
PMCID: PMC8358220

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