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Article

High-grade transformation of pancreatic neuroendocrine tumor associated with TP53 mutations: A diagnostic pitfall mimicking neuroendocrine carcinoma.

Pathology international - 1 Aug 2022

Tanaka Mariko, Shinozaki-Ushiku Aya, Kunita Akiko, Yasunaga Yoichi, Akamatsu Nobuhisa, Hasegawa Kiyoshi, Ushiku Tetsuo

Abstract excerpt

Among pancreatic neuroendocrine neoplasms, mutations in ATRX, DAXX, and MEN1 are specific to neuroendocrine tumors (NETs), whereas TP53 and RB1 mutations are characteristic of neuroendocrine carcinomas (NECs). We report a case of pancreatic NET that underwent high-grade transformation associated with acquisition of TP53 mutations. The primary pancreatic tumor consisted of conventional grade 2 NET with loss of...

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Identifiers

PMID: 35698921
DOI: 10.1111/pin.13252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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