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Article

Adult ADHD with comorbid major depression shows a distinguishable polygenic pattern and negative cognitive style.

Translational psychiatry - 4 Apr 2026

Kranz Thorsten M, McNeill Rhiannon V, Jacob Christian P, Ahrens Kira F, Neumann Rebecca J, Plichta Michael M, Kollmann Bianca, Streit Fabian, Tüscher Oliver, Lieb Klaus, Weber Heike, Romanos Marcel, Lesch Klaus-Peter, Reif Andreas, Kittel-Schneider Sarah, Ziegler Georg C

Abstract excerpt

Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder, and comorbidity with other mental diseases is common. Specifically, adult ADHD (aADHD) is highly comorbid with major depressive disorder (MDD). A genetic correlation between ADHD and MDD might underlie the risk of comorbidity of both disorders. However, whether patients with ADHD and comorbid MDD differ genetically...

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Share to Attention Deficit Disorder with Hyperactivity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41935030
DOI: 10.1038/s41398-026-04008-3
PMCID: PMC13079749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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