Lack of evidence for the involvement of non-canonical pyroptosis in a mouse model of thoracic aortic dissection.

Abstract excerpt

Thoracic aortic dissection (TAD) is a severe aortic disease with high mortality. One of its pathological hallmarks is aortic smooth muscle cell death, but the death modalities are not fully known. Recent studies suggest an association of pyroptosis with aortic diseases, but whether it contributes to TAD remains unknown. Here, we modeled TAD by feeding 3-week-old mice with β-aminopropionitrile (BAPN), a lysyl...

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• Aorta, Thoracic
• Aortic Aneurysm, Thoracic
• Aortic Dissection
• Caspases
• Disease Models, Animal