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Article

Analysis of the Genomic Landscape in ALK+ NSCLC Patients Identifies Novel Aberrations Associated with Clinical Outcomes.

Molecular cancer therapeutics - 1 Sept 2019

Couëtoux du Tertre Mathilde, Marques Maud, Tremblay Lise, Bouchard Nicole, Diaconescu Razvan, Blais Normand, Couture Christian, Pelsser Vincent, Wang Hangjun, Higenell Valerie, Izzi Luisa, Gambaro Karen, Hoffert Cyrla, Srivastava Archana, Spatz Alan, Rousseau Caroline, McNamara Suzan, Cohen Victor, Batist Gerald, Agulnik Jason

Abstract excerpt

Rearrangements in the anaplastic lymphoma kinase (ALK) gene are found in approximately 5% of non-small cell lung carcinoma (NSCLC). Here, we present a comprehensive genomic landscape of 11 patients with ALK+ NSCLC and investigate its relationship with response to crizotinib. Using whole-exome sequencing and RNAseq data, we identified four rare ALK fusion partners (HIP1, GCC2, ERC1, and SLC16A7) and one novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31243098
DOI: 10.1158/1535-7163.MCT-19-0105

Genes

ALK
TP53
CEP55
EGFR
EML4
ERC1
GCC2
HIP1
SLC16A7

Provenance

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