Article
Clinicogenomic and Histopathologic Analyses of Supermassive Intrahepatic Cholangiocarcinoma and the Role of Ablative Radiotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2026
Abi Jaoude Joseph, Lau Alexandria, Yuan Yinyin, Meimoun Noah S, De Brian, Liao Kaiping, Kouzy Ramez, Nieves-Jimenez Humberto R, Poenisch Falk, Balter Peter A, Brock Kristy K, Sawakuchi Gabriel O, Vauthey Jean-Nicolas, Tzeng Ching-Wei D, Shamsutdinova Diana, Lazar Alexander J, Chatterjee Deyali, Holliday Emma B, Smith Grace L, Minsky Bruce D, Das Prajnan, Koong Albert C, Lee Sunyoung S, Tran Cao Hop S, Javle Milind, Kwong Lawrence, Koay Eugene J, Ludmir Ethan B
Abstract excerpt
PURPOSE: Ablative radiotherapy (RT) improves clinical outcomes in patients with unresectable intrahepatic cholangiocarcinoma (ICC). Applicability to "supermassive" ICC remains uncertain given smaller tumor diameters in previous studies. We hypothesize that supermassive ICCs are not mutationally or histopathologically different from nonsupermassive ICCs and so would respond favorably to ablative RT. EXPERIMENTAL...
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