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Article

FSHR and LHR functional compensation reveals the mechanism and treatment of Ovarian Hyperstimulation Syndrome.

Nature communications - 1 Apr 2026

Lai Shanshan, Huang Yongjie, Ma Su, Hao Hongying, Dai Ao, Yan Xiaofei, Yang Jiabao, Wang Shuqian, Ren Qingqing, Zhang Yan, Hu Peng, Li Jing, Zheng Xiaowei, Brosius Juergen, Deng Cheng

Abstract excerpt

Gain-of-function mutations in the human follicle-stimulating hormone receptor (FSHR) cause spontaneous ovarian hyperstimulation syndrome (OHSS), a serious reproductive disorder. However, the molecular physiology and treatment options for OHSS remain elusive. Notably, estrildid finches naturally carry an FSHR variant (Thr449Ala) analogous to the pathogenic mutation in humans yet are resistant to OHSS. Here we show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41916974
DOI: 10.1038/s41467-026-71338-7
PMCID: PMC13201656

Genes

FSHR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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