Article
A Comprehensive Assessment of the Causal Relationship between Atopic Conditions and Pancreatic Cancer Risk: A Two-Sample Mendelian Randomization Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Jun 2026
He Jiangchuan, Sabroso-Lasa Sergio, Coscia Claudia, López de Maturana Evangelina, Alonso Lola, Lawlor Rita T, Carrato Alfredo, Alvarez Gallego Rafael, Iglesias Mar, Molero Xavier, Michalski Christoph, Perea Jose, Löhr Matthias, O'Rorke Michael A, Barberá Victor M, Tardon Adonina, Farré Antoni, Crnogorac-Jurcevic Tatjana, Domínguez-Muñoz Enrique, Gress Thomas M, Greenhalf William, Sharp Linda, Moreno-Oya Ane, Costello Eithne, Kleeff Jorg, Kong Bo, Mora Josefina, O'Driscoll Damian, Scarpa Aldo, Ye Weimin, Real Francisco X, Malats Núria
Abstract excerpt
BACKGROUND: Observational studies consistently report reduced pancreatic ductal adenocarcinoma (PDAC) risk among individuals with atopic conditions (asthma and rhinitis); however, the underlying biological mechanism remains unclear. This Mendelian randomization (MR) study investigated the potential causal relationship between atopy and PDAC by leveraging multiple genome-wide association studies (GWAS) and...
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