Article
The dual role of P2RY12: impact of polymorphism and expression on ischemic events and bleeding in patients with ST-segment elevation myocardial infarction receiving antithrombotic therapy.
Journal of thrombosis and haemostasis : JTH - 1 Jul 2026
Li Jiqing, Gong Zheng, Wang Shikun, Gu Jianhua, Wu Shuo, Pang Jiaojiao, Chen Yuguo
Abstract excerpt
BACKGROUND: The influence of P2RY12 polymorphisms and expression on the ischemia-bleeding balance in patients with ST-segment elevation myocardial infarction (STEMI) remains poorly defined. OBJECTIVES: To evaluate the associations of P2RY12 with major adverse cardiovascular events (MACE) and bleeding risk in STEMI patients treated with ticagrelor. METHODS: This prospective cohort study enrolled patients with...
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