Article

The Pan-African Natural Products Library Compounds Oleanolic Acid, Poinsettifolin B, and Rhuschalcone III Disrupt SARS-CoV-2 Spike-Host ACE2 Interactions and SARS-CoV-2 Replication

2026-02-25

Abstract excerpt

Natural product (NP)-based chemical libraries are a rich source of antiviral compounds that can serve as the basis for new therapeutic leads to treat viral diseases, particularly toward individuals lacking sustained access to existing vaccines and therapeutics. To identify new NP-based inhibitors of SARS-CoV-2 cellular entry and viral replication, we screened the pan-African Natural Products Library (p-ANAPL), a c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7ae37276-67b0-5119-b64d-e9ae43e47021
DOI: 10.20944/preprints202602.1425.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Pan-African Natural Products Library Compounds Oleanolic Acid, Poinsettifolin B, and Rhuschalcone III Disrupt SARS-CoV-2 Spike-Host ACE2 Interactions and SARS-CoV-2 ReplicationDOI 10.20944/preprints202602.1425.v1Read

Lancemaside A from Codonopsis lanceolata is a broad-spectrum antiviral agent against SARS-CoV-2 and variants of concernSemantic proximity Read

Molecular Docking Analyses of Phytochemicals Obtained from African Antiviral Herbal Plants Exhibit Inhibitory Activity against Therapeutic Targets of SARS-CoV-2Semantic proximity Read

Screening of Botanical Drugs against SARS-CoV-2 EntrySemantic proximity Read

In silico screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19Semantic proximity Read

Emerging Strains Of SARS-Cov2 And Their Inhibition by The Use of Phytochemicals: An In-Silico AnalysisSemantic proximity Read

Preclinical and Clinical Study of Efficacy of NAOQ19 against SARS-COV2: A Comprehensive EvaluationSemantic proximity Read

Antiviral Activity and Underlying Mechanism of Moslae Herba Aqueous Extract for Treating SARS-CoV-2Semantic proximity Read

Discovery and Evaluation of Entry Inhibitors for SARS-CoV-2 and Its Emerging Variants.Semantic proximity Read

Evaluation of the inhibitory potential of Bioactive compounds against SARS-CoV2 by in-silico approachSemantic proximity Read

Homology Modeling and Molecular Dynamics-Driven Search for Natural Inhibitors That Universally Target Receptor-Binding Domain of Spike Glycoprotein in SARS-CoV-2 Variants.Semantic proximity Read

Annual SZ® A Novel Formulation For COVID-19 Therapy Clinical Trial StudiesSemantic proximity Read

Structure-Based Identification of Natural Products as SARS-CoV-2 Mpro Antagonist from Echinacea angustifolia Using Computational ApproachesSemantic proximity Read