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Article

Epigenetic regulation of HLA-G : implications for recurrent pregnancy loss.

Molecular biology reports - 28 Mar 2026

M Shaker Mai, M Elaraby Nesma, A Shalabi Taghreed

Abstract excerpt

BACKGROUND: Recurrent pregnancy loss (RPL) is a multifactorial reproductive disorder in which epigenetic dysregulation has been increasingly implicated. DNA methylation of immune-regulatory genes, particularly human leukocyte antigen-G (HLA-G), may impair maternal–fetal immune tolerance and contribute to adverse pregnancy outcomes. This study investigated the association between HLA-G promoter methylation and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41902993
DOI: 10.1007/s11033-026-11664-7

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