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Article

HFE p.C282Y Polymorphism and Risk of Metabolic Syndrome Components: Systematic Review and Meta-Analysis.

Medicina (Kaunas, Lithuania) - 20 Mar 2026

Kaldarkhan Dana, Nuskabayeva Gulnaz, Nurdinov Nursultan, Saruarov Yerbolat, Tatykayeva Ugilzhan, Oshibayeva Ainash, Sadykova Karlygash

Abstract excerpt

Background and Objectives: Metabolic syndrome is a common condition associated with a higher risk of diabetes and cardiovascular disease. Altered iron metabolism, especially iron overload, may play a role in the development of insulin resistance, hypertension, and other metabolic abnormalities. Although the p.C282Y polymorphism of the HFE gene affects iron regulation and may contribute to these metabolic changes,...

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Share to HFE gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemochromatosis Protein

Share to Hypertension

Share to Metabolic Syndrome

Share to Polymorphism, Genetic

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Share to Triglycerides

Source

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Identifiers

PMID: 41901670
DOI: 10.3390/medicina62030589
PMCID: PMC13028029

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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HFE p.C282Y Polymorphism and Risk of Metabolic Syndrome Components: Systematic Review and Meta-Analysis.PMID 41901670Read ↗

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