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Article

C282Y Homozygosity Increases Erythrocyte Turnover and Decreases HbA1c-A Population-Based Study.

International journal of molecular sciences - 5 Mar 2026

Hillingsø Rebekka, Kjaergaard Alisa Devedzic, Larsen Morten Kranker, Mandrup-Poulsen Thomas, Poulsen Henrik Enghusen, Mottelson Mathis, Petersen Jesper Brix, Nordestgaard Børge Grønne, Hasselbalch Hans Carl, Bojesen Stig Egil, Helby Jens, Glenthøj Andreas, Ellervik Christina

Abstract excerpt

Individuals with C282Y/C282Y in the hemochromatosis HFE gene have increased iron levels, which catalyze the formation of reactive oxygen species, and an increased risk of diabetes. These individuals may have disproportionately lower hemoglobin A1c (HbA1c) due to increased erythrocyte turnover, decreased erythrocyte counts, and/or an increased mean corpuscular hemoglobin concentration (MCHC). In the Copenhagen...

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Identifiers

PMID: 41828626
DOI: 10.3390/ijms27052410
PMCID: PMC12986277

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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