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Article

HFE genetic variability, body iron stores, and the risk of type 2 diabetes in U.S. women.

Diabetes - 1 Dec 2005

Qi Lu, Meigs James, Manson JoAnn E, Ma Jing, Hunter David, Rifai Nader, Hu Frank B

Abstract excerpt

To determine whether the HFE gene variants H63D and C282Y are associated with body iron stores and the risk of type 2 diabetes, we conducted a nested case-control study of 714 incident cases of type 2 diabetes and 1,120 matching control subjects in a prospective cohort, the Nurses' Health Study. In both healthy control and diabetic case subjects, H63D homozygosity, C282Y, and the compound heterozygotes were...

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Identifiers

PMID: 16306377
DOI: 10.2337/diabetes.54.12.3567

Genes

HFE

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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HFE genetic variability, body iron stores, and the risk of type 2 diabetes in U.S. women.PMID 16306377Read ↗

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Typical type 2 diabetes mellitus and HFE gene mutations: a population-based case - control study.Semantic proximity Read ↗

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