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SULT and UGT Genetic Variants Modulate Side Effect Profiles in South African Breast Cancer Patients Treated with Tamoxifen.

Genes - 24 Feb 2026

Kruger Bianca, Chimusa Emile, Abera Aron, Singh Jesmika, Shamley Delva, Dandara Collet

Abstract excerpt

Background: Tamoxifen remains the cornerstone of endocrine therapy for hormone receptor-positive breast cancer across Africa. Understanding the factors that influence tamoxifen tolerability is critical, as treatment-related side effects can reduce adherence and compromise therapeutic outcomes. Yet, the contribution of pharmacogenetic variation to tamoxifen-related toxicity remains poorly characterized in African...

Topics

Adult
Female
Humans
Middle Aged
Antineoplastic Agents, Hormonal
Arylsulfotransferase
Breast Neoplasms
Drug-Related Side Effects and Adverse Reactions
Glucuronosyltransferase
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

South Africa

Southern African People

Tamoxifen

Source

Open in PubMed Open full text

Identifiers

PMID: 41898786
DOI: 10.3390/genes17030252
PMCID: PMC13025226

Genes

SULT1E1
CYP3A4
SULT1A1
UGT2B7
SULT1A2
UGT1A4
UGT2B15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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