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Article

SULT and UGT Genetic Variants Modulate Side Effect Profiles in South African Breast Cancer Patients Treated with Tamoxifen.

Genes - 24 Feb 2026

Kruger Bianca, Chimusa Emile, Abera Aron, Singh Jesmika, Shamley Delva, Dandara Collet

Abstract excerpt

Background: Tamoxifen remains the cornerstone of endocrine therapy for hormone receptor-positive breast cancer across Africa. Understanding the factors that influence tamoxifen tolerability is critical, as treatment-related side effects can reduce adherence and compromise therapeutic outcomes. Yet, the contribution of pharmacogenetic variation to tamoxifen-related toxicity remains poorly characterized in African...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Drug-Related Side Effects and Adverse Reactions

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 41898786
DOI: 10.3390/genes17030252
PMCID: PMC13025226

Genes

SULT1E1
CYP3A4
SULT1A1
UGT2B7
SULT1A2
UGT1A4
UGT2B15

Provenance

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SULT and UGT Genetic Variants Modulate Side Effect Profiles in South African Breast Cancer Patients Treated with Tamoxifen.PMID 41898786Read ↗

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