Article
Epimutations in migraine and in medication overuse headache: a longitudinal study after acute medication withdrawal.
The journal of headache and pain - 27 Mar 2026
Ferraresi Francesca, Favoni Valentina, Mascarella Davide, Pirazzini Chiara, Kwiatkowska Katarzyna Malgorzata, Ravaioli Francesco, Bacalini Maria Giulia, Dall'olio Daniele, Castellani Gastone, Sala Claudia, Pierangeli Giulia, Cortelli Pietro, Gentilini Davide, Calzari Luciano, Terlizzi Rossana, Garagnani Paolo, Cevoli Sabina
Abstract excerpt
BACKGROUND: Headache disorders are among the leading causes of neurological disability worldwide, affecting over half of the global population. Recent data indicate that headache prevalence among young people increased by 23.7% between 1990 and 2021. Migraine, a highly disabling primary headache, significantly impacts daily life, yet timely and accurate diagnosis remains challenging. Many patients self-manage...
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