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Article

Development of an ARMS-qPCR Strategy for the Rapid Genetic Diagnosis of Nagashima-Type Palmoplantar Keratoderma.

The Journal of dermatology - 1 May 2026

Zhang Jingya, Liu Yihe, Liu Juan, Mo Ran, Mao Xinyu, Yang Yong, Chen Zhiming

Abstract excerpt

Nagashima-type palmoplantar keratoderma, recently termed as SERPINB7/SERPINA12-palmoplantar epidermal differentiation disorders (pEDD) is the most prevalent palmoplantar keratoderma in East Asia, caused by variants in the SERPINB7 and SERPINA12. Sanger sequencing and next-generation sequencing (NGS) are the gold standard methods for detecting these variants, but their complexity and high cost limit clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41891421
DOI: 10.1111/1346-8138.70239

Genes

SERPINA12
SERPINB7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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