Article

Clinical and genetic characteristics of Nagashima-type palmoplantar keratoderma: A single-centre cross-sectional study

2026-07-03

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Nagashima-type palmoplantar keratoderma (NPPK) is a rare autosomal recessive skin disease caused by pathogenetic variants in <italic>SERPINB7</italic> . However, the clinical and genetic characteristics of NPPK remain poorly understood. To address this gap, we conducted a retrospective analysis of 85 patients with NPPK at West China Hospital, Sichuan Univers...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b598b7f1-bd2a-5662-bebc-ce941069725f
DOI: 10.21203/rs.3.rs-9987530/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clinical and genetic characteristics of Nagashima-type palmoplantar keratoderma: A single-centre cross-sectional studyDOI 10.21203/rs.3.rs-9987530/v1Read

Investigation of Nagashima-type palmoplantar keratoderma in China: A cross-sectional study of 234 patients.Semantic proximity Read

Nagashima-Type Palmoplantar Keratosis: Clinical Characteristics, Genetic Characterization, and Clinical Management.Semantic proximity Read

History and prospects of Nagashima‐type palmoplantar keratosis, the most common palmoplantar keratoderma in east Asian populationsSemantic proximity Read

Two novel mutations of SERPINB7 in eight cases of Nagashima-type palmoplantar keratosis in the Chinese population.Semantic proximity Read

Large-Scale Cohort Study on the Genetic and Phenotypic Findings of Palmoplantar Keratodermas in the Chinese Population.Semantic proximity Read

Nagashima-type palmoplantar keratosis in Finland caused by a SERPINB7 founder mutationSemantic proximity Read

Hereditary palmoplantar keratodermas. Part I. Non-syndromic palmoplantar keratodermas: classification, clinical and genetic features.Semantic proximity Read

Nagashima-type palmoplantar keratosis in a Chinese Han population.Semantic proximity Read

Hereditary palmoplantar keratoderma: A practical approach to the diagnosisSemantic proximity Read

Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis.Semantic proximity Read

Palmoplantar keratoderma (PPK): acquired and genetic causes of a not so rare disease.Semantic proximity Read

Potential digenic inheritance of SERPINB7 and SERPINA12 variants in Chinese patients with Nagashima-type palmoplantar keratosisSemantic proximity Read