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Article

Large-Scale Cohort Study on the Genetic and Phenotypic Findings of Palmoplantar Keratodermas in the Chinese Population.

Experimental dermatology - 1 Jul 2026

Wang Xinyi, Sun Weiwei, Zhang Cheng, Wang Yumeng, Li Mingyang, Ge Hongsong, Zheng Luyao, Cao Qiaoyu, Li Yue, Wang Shucui, Zhao Anqi, Pan Chaonan, Zeng Yibin, Li Ming

Abstract excerpt

Palmoplantar keratoderma (PPK) is a heterogeneous group of skin diseases, characterised by excessive keratinization and hyperplasia of the palms and soles. However, accurate molecular diagnosis remains challenging due to the low prevalence of hereditary forms. This study analysed the phenotype and genotype distribution in a large cohort of Chinese patients with PPK, aiming to clarify the genetic aetiology and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42384829
DOI: 10.1111/exd.70311

Genes

SERPINB7
SERPINA12
AQP5
KRT16
KRT6A
KRT9
SLURP1
TRPV3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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