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Article

Two novel mutations of SERPINB7 in eight cases of Nagashima-type palmoplantar keratosis in the Chinese population.

The Journal of dermatology - 1 May 2022

Xiao Tong, Liu Yan, Wang Tian, Ren Junru, Xia Yumin, Wang Xiaopeng

Abstract excerpt

Nagashima-type palmoplantar keratosis (NPPK) is a diffuse, autosomal recessive, and non-epidermolytic palmoplantar keratosis caused by mutations in the SERPINB7 gene, a member of the serine protease inhibitor superfamily. Genetic studies and case reports suggest that NPPK is the most common palmoplantar keratosis in East Asia but rare in Western countries. This study reports eight NPPK patients in seven pedigrees...

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Identifiers

PMID: 35178744
DOI: 10.1111/1346-8138.16310
PMCID: PMC9303684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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