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Article

Data-driven phenotypic clustering of idiopathic restless legs syndrome and its longitudinal clinical correlates.

Sleep medicine - 1 Jul 2026

Hwang Sungeun, Bang Se Young, Jung Ki-Young

Abstract excerpt

OBJECTIVES: Restless legs syndrome (RLS) shows substantial heterogeneity in symptoms, comorbidity, and treatment response. This study aimed to identify clinically meaningful phenotypic subgroups of idiopathic RLS using an unsupervised, data-driven clustering and to evaluate associations with longitudinal clinical outcomes. METHODS: We retrospectively analyzed 360 patients with idiopathic RLS who had ≥1 year of...

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PMID: 41887116
DOI: 10.1016/j.sleep.2026.108905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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