Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the H19/miR-423-5p/DTX3L Axis in Enhancing the Malignant Phenotype of Nasopharyngeal Carcinoma Cells.

Biological & pharmaceutical bulletin - 1 Jan 2026

Jiang Li, Wang Chunrui, Hu Qi, Xu Shijia, Guo Qi

Abstract excerpt

Deltex E3 ubiquitin ligase 3L (DTX3L) is a well-established ubiquitin ligase implicated in various cancers, but its role in nasopharyngeal carcinoma (NPC) progression remains elusive. In this study, we confirmed for the first time that DTX3L was highly expressed in C666-1 and NPC/HK1 NPC cells. DTX3L overexpression promoted NPC cell proliferation, invasion, and migration. Conversely, DTX3L knockdown suppressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cell Movement
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Nasopharyngeal Carcinoma

Share to Nasopharyngeal Neoplasms

Share to RNA, Long Noncoding

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 41882821
DOI: 10.1248/bpb.b25-00698

Genes

DTX3L
HK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the H19/miR-423-5p/DTX3L Axis in Enhancing the Malignant Phenotype of Nasopharyngeal Carcinoma Cells.PMID 41882821Read ↗

Long Noncoding RNA NHEG1 Drives β-Catenin Transactivation and Neuroblastoma Progression through Interacting with DDX5Semantic proximity Read ↗

Cullin 4A/protein arginine methyltransferase 5 (CUL4A/PRMT5) promotes cell malignant phenotypes and tumor growth in nasopharyngeal carcinoma.Semantic proximity Read ↗

DTL promotes glycolysis and tumor progression in nasopharyngeal carcinoma cells by degrading KAT2B and activating the PI3K/AKT/mTOR pathwaySemantic proximity Read ↗

LHX2 facilitates the progression of nasopharyngeal carcinoma via activating the autocrine secretion of FGF1Semantic proximity Read ↗

METTL1-driven epitranscriptomic enhancement of TXNDC12 boosts c-Myc stability through USP5 in HNSCCSemantic proximity Read ↗

CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus–Associated Head and Neck CancersSemantic proximity Read ↗

BRD7 enhances the radiosensitivity of nasopharyngeal carcinoma cells by negatively regulating USP5/METTL3 axis-mediated homologous recombination repairSemantic proximity Read ↗

Deubiquitinating enzyme JOSD2 promotes hepatocellular carcinoma progression through interacting with and inhibiting CTNNB1 degradationSemantic proximity Read ↗

LncRNA CEBPA-DT promotes liver cancer metastasis through DDR2/β-catenin activation via interacting with hnRNPCSemantic proximity Read ↗

UBR5 regulates proliferation and radiosensitivity in human laryngeal carcinoma via the p38/MAPK signaling pathwaySemantic proximity Read ↗

The RNA-binding protein DDX39B promotes colorectal adenocarcinoma progression by stabilizing DCLK1Semantic proximity Read ↗

CDCP1 promotes the malignant phenotypes of nasopharyngeal carcinoma via the Wnt/β-catenin signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.