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Article

Genetic variants associated with systemic inflammatory disease associate with temporomandibular symptoms with or without periodontitis.

PloS one - 1 Jan 2026

Lucas Courtney, Baxter Dylan, Deeley Kathleen, Shah Nilesh, Pugliano Antonio, Silva Renato, Letra Ariadne, Bezamat Mariana, Almarza Alejandro, Taboas Juan, Vieira Alexandre R

Abstract excerpt

INTRODUCTION: Associations of genetic polymorphisms reported to play a role in systemic inflammatory diseases may serve as proxies to assess predisposition for oral diseases, as well as identify biomarkers to support preventive measures and targeted therapies. Our goal was to assess if genetic variants previously associated with systemic inflammation are associated with temporomandibular symptoms (TMS). METHODS:...

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Topics

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Share to Genetic Predisposition to Disease
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Inflammation

Share to Periodontitis

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Temporomandibular Joint Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 41880348
DOI: 10.1371/journal.pone.0328855
PMCID: PMC13016321

Genes

MMP9
AXIN2
ADAM10
AQP5
BRINP3
CA9
GSK3B
IL10
IL17A
IL1B
IL4
MMP2
MYO1H
TGFB1
WNT11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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