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Article

Distinct Genetic Profiles Associated With Subretinal Drusenoid Deposits and Cardiovascular Risk in Age-Related Macular Degeneration.

Translational vision science & technology - 2 Mar 2026

Lishinsky-Fischer Natan, Jaskoll Shlomit, Kramer Adi, Grunin Michelle, Elbaz-Hayoun Sarah, Rinsky Batya, Chowers Itay, Levy Jaime

Abstract excerpt

Purpose: Subretinal drusenoid deposits (SDDs) are increasingly recognized as a distinct phenotype in age-related macular degeneration (AMD) and may be linked to cardiovascular disease (CVD). This study aims to explore whether AMD patients with SDDs carry a distinct genetic profile related to CVD risk compared to those without SDDs. Methods: In a retrospective cohort of 459 AMD patients with genotyping and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41879420
DOI: 10.1167/tvst.15.3.27
PMCID: PMC13034995

Genes

ARHGAP21
ARMS2
CFH
COL4A3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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