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Article

Analysis of rpoB mutations associated with rifampicin resistance in Mycobacterium tuberculosis isolates in Malawi.

BMC infectious diseases - 23 Mar 2026

Soko Stewart, Kumwenda Pizga

Abstract excerpt

BACKGROUND: Rifampicin-resistant tuberculosis (RR-TB) remains a major challenge for TB control in Malawi, particularly in densely populated districts such as Blantyre. Most rifampicin resistance is caused by mutations in the rifampicin resistance determining region (RRDR) of the RNA Polymerase Beta gene (rpoB). This study characterized the distribution of RRDR mutations detected by GeneXpert MTB/RIF. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41872779
DOI: 10.1186/s12879-026-13126-8
PMCID: PMC13134099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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