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Does Xpert® MTB/RIF assay give rifampicin resistance results without identified mutation? Review of cases from Addis Ababa, Ethiopia.

BMC infectious diseases - 30 Jan 2020

Alemu Ayinalem, Tadesse Mengistu, Seid Getachew, Mollalign Helina, Eshetu Kirubel, Sinshaw Waganeh, Abebaw Yeshiwork, Amare Misikir, Dagne Biniyam, Diriba Getu, Yenew Bazezew, Getu Melak, Zerihun Betselot

Abstract excerpt

BACKGROUND: Xpert® MTB/RIF assay is currently used in Ethiopia for the rapid diagnosis of Mycobacterium tuberculosis (MTB) and mutations that confer Rifampicin resistance. Rifampicin resistance is determined based on any mutation in the 81 bp of rpoB gene using five overlapping probes represented as Probe A (codons 507-511), Probe B (codons 512-518), Probe C (codons 518-523), Probe D (codons 523-529) and Probe E...

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PMID: 32000702
DOI: 10.1186/s12879-020-4817-2
PMCID: PMC6993378

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