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Article

Mouse adaptation of influenza B virus increases replication in the upper respiratory tract and results in droplet transmissibility in ferrets.

Scientific reports - 3 Nov 2015

Kim Eun-Ha, Park Su-Jin, Kwon Hyeok-Il, Kim Se Mi, Kim Young-il, Song Min-Suk, Choi Eun-Ji, Pascua Philippe Noriel Q, Choi Young-Ki

Abstract excerpt

To investigate the molecular changes that allow influenza B viruses to adapt to new mammalian hosts, influenza B/Florida/04/2006 was serially passaged in BALB/c mice until highly virulent. The viral factors underlying this transition were then investigated in mice and ferrets. Five viruses, including the wild-type virus (P0), three intermediate viruses (P5, P9, and P12), and a lethal mouse-adapted virus (P17...

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Source

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Identifiers

PMID: 26526113
DOI: 10.1038/srep15940
PMCID: PMC4630645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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