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Interactive effects of telomere length and genetic variants on Alzheimer disease risk across multiple ancestral populations.

Alzheimer's research & therapy - 20 Mar 2026

Khurshid Zainab, Tong Tong, Olayinka Oluwatosin, Farrell John J, Zhu Congcong, Martin Eden R, Bush William S, Pericak-Vance Margaret A, Wang Li-San, Schellenberg Gerard D, Haines Jonathan L, Lunetta Kathryn L, Zhang Xiaoling, Farrer Lindsay A

Abstract excerpt

BACKGROUND: Telomere length (TL), a biomarker of biological aging, but its association with Alzheimer’s disease (AD) remains unclear. METHODS: We estimated TL in whole-genome sequencing data from 35,014 Alzheimer’s Disease Sequencing Project participants using TelSeq, which after quality control yielded a dataset including 6,973 persons of European ancestry (EA), 4,188 African Americans (AA), 4,005 Caribbean...

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Identifiers

PMID: 41857676
DOI: 10.1186/s13195-026-02005-8
PMCID: PMC13122948

Genes

APOE
BSN
IL15
INPP4B
MST1
PLK1
SEMA6A
TBC1D22A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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