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A One Health study of Klebsiella pneumoniae species complex plasmids shows a highly diverse and ecologically adaptable plasmidome.

Microbial genomics - 1 Feb 2026

Winkler Mia A, Hetland Marit A K, Kaspersen Håkon Pedersen, Bakksjø Ragna-Johanne, Bernhoff Eva, Fostervold Aasmund, Hawkey Jane, Lunestad Bjørn-Tore, Marathe Nachiket P, Raffelsberger Niclas, Samuelsen Ørjan, Sunde Marianne, Sundsfjord Arnfinn, Lam Margaret M C, Löhr Iren H

Abstract excerpt

Plasmids play a pivotal role in the horizontal gene transfer (HGT) of antimicrobial resistance (AMR) and virulence determinants among bacteria. Members of the Klebsiella pneumoniae species complex (KpSC) can colonize humans, animals and various environments and frequently cause nosocomial and community-acquired infections in humans. While plasmid-borne AMR genes are prevalent in clinical strains, the diversity,...

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Identifiers

PMID: 41712274
DOI: 10.1099/mgen.0.001629
PMCID: PMC12919850

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