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Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance

4 Apr 2022

Abstract excerpt

BACKGROUND: Carbapenem-resistant Enterobacterales (CRE) are an urgent global health threat. Inferring the dynamics of local CRE dissemination is currently limited by our inability to confidently trace the spread of resistance determinants to unrelated bacterial hosts. Whole-genome sequence comparison is useful for identifying CRE clonal transmission and outbreaks, but high-frequency horizontal gene transfer (HGT)...

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PMID: 35379360
DOI: 10.1186/s13073-022-01040-y

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