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Comparative proteomic profiling of the ovine and human PBMC inflammatory response

28 Jun 2024

Abstract excerpt

Abstract Understanding the cellular and molecular mechanisms of inflammation requires robust animal models. Sheep are commonly used in immune-related studies, yet the validity of sheep as animal models for immune and inflammatory diseases remains to be established. This cross-species comparative study analyzed the in vitro inflammatory response of ovine (oPBMCs) and human PBMCs (hPBMCs) using mass spectrometry,...

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PMID: 38942936
DOI: 10.1038/s41598-024-66059-0

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