Epigenetic Modulation of the ACE System Underlies the Slow Aerobic Muscle Phenotype and Metabolic Exercise Response.

doi:10.1096/fj.202504082R

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Article

Epigenetic Modulation of the ACE System Underlies the Slow Aerobic Muscle Phenotype and Metabolic Exercise Response.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 31 Mar 2026

Martin Flück, Gasser Benedikt, Marie-Noëlle Giraud

Abstract excerpt

Epigenetic regulation of the angiotensin-converting enzyme (ACE)-particularly CpG methylation within its promoter-may modulate gene expression and skeletal muscle adaptation to endurance exercise, complementing the known effects of the ACE I/D polymorphism (rs1799752). We hypothesized that ACE promoter methylation correlates with markers of aerobic metabolism and interacts with genotype and enzyme activity to...

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PMID: 41847930
DOI: 10.1096/fj.202504082R
PMCID: PMC12997149

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