Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity.

doi:10.1152/physiolgenomics.00024.2014

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Article

Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity.

Physiological genomics - 15 Oct 2014

Rowlands David S, Page Rachel A, Sukala William R, Giri Mamta, Ghimbovschi Svetlana D, Hayat Irum, Cheema Birinder S, Lys Isabelle, Leikis Murray, Sheard Phillip W, Wakefield St John, Breier Bernhard, Hathout Yetrib, Brown Kristy, Marathi Ramya, Orkunoglu-Suer Funda E, Devaney Joseph M, Leiken Benjamin, Many Gina, Krebs Jeremy, Hopkins Will G, Hoffman Eric P

Abstract excerpt

Epigenomic regulation of the transcriptome by DNA methylation and posttranscriptional gene silencing by miRNAs are potential environmental modulators of skeletal muscle plasticity to chronic exercise in healthy and diseased populations. We utilized transcriptome networks to connect exercise-induced differential methylation and miRNA with functional skeletal muscle plasticity. Biopsies of the vastus lateralis were...

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Identifiers

PMID: 25138607
DOI: 10.1152/physiolgenomics.00024.2014
PMCID: PMC4200377

Genes

NRF1
SLC27A4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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