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[Cause Analysis of HLA-B Allele Missed Detection Based on AlltypeTM FastplexTM Next Generation Sequencing].

Zhongguo shi yan xue ye xue za zhi - 1 Feb 2026

Quan Zhan-Rou, Yang Bing-Na, Liu Jie, Zou Hong-Yan

Abstract excerpt

OBJECTIVE: To investigate the missed detection of HLA-B allele in one case using AlltypeTM FastplexTM next generation sequencing (NGS), and evaluate the accuracy and limitations of NGS in HLA genotyping. METHODS: HLA routine detection was performed using PCR-sequence-specific oligonucleotide probe (SSOP) and AlltypeTM FastplexTM NGS. After discovering a sample from a patient with Glanzmann's thrombasthenia that...

Topics

Humans
Alleles
HLA-B Antigens
High-Throughput Nucleotide Sequencing
Genotype
Histocompatibility Testing
Sequence Analysis, DNA
Polymerase Chain Reaction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41846366
DOI: 10.19746/j.cnki.issn.1009-2137.2026.01.037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41846366-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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