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[The Polymorphism Analysis of HLA Class II Alleles Based on Next-Generation Sequencing and Prevention Strategy for Allele Dropout].

Zhongguo shi yan xue ye xue za zhi - 1 Apr 2024

Gao Su-Qing, Quan Zhan-Rou, Zhong Yan-Ping, Chen Hao, He Liu-Mei, Zou Hong-Yan, Deng Zhi-Hui

Abstract excerpt

OBJECTIVE: To investigate the accuracy of next-generation sequencing technology (NGS) in detecting the polymorphisms of HLA-DRB1, DQB1, DQA1, DRB3, DRB4, DRB5, DPA1 and DPB1 alleles in randomly-selected unrelated healthy individuals from Shenzhen Han population, investigate the potential reason for HLA-DRB1 allele dropout in routine NGS, and establish an internal quality control system. METHODS: NGS-based HLA...

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Identifiers

PMID: 38660873
DOI: 10.19746/j.cnki.issn.1009-2137.2024.02.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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