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Article

The unphosphorylated, closed form of ezrin binds to RNA to maintain a metastatic phenotype in osteosarcoma cells.

Science signaling - 17 Mar 2026

Deniz Emre, Tiwari Prakriti, Tiwari Purushottam B, Glasgow Eric, Harris Brent T, Tiwari Anup, Hou Chunyan, Ma Junfeng, Toretsky Jeffrey A, Üren Aykut

Abstract excerpt

Ezrin is a cytoplasmic protein that can exist in multiple conformations that are regulated by phosphorylation at Thr567. The phosphorylated, open form of ezrin generally has been considered the active form because it translocates to the plasma membrane. In contrast, the unphosphorylated, closed form of ezrin is sequestered in the cytoplasm and is considered inactive, although it directly interacts with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41843652
DOI: 10.1126/scisignal.ady8367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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