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Article

Ezrin Inhibition Up-regulates Stress Response Gene Expression

3 May 2016

Abstract excerpt

Ezrin is a member of the ERM (ezrin/radixin/moesin) family of proteins that links cortical cytoskeleton to the plasma membrane. High expression of ezrin correlates with poor prognosis and metastasis in osteosarcoma. In this study, to uncover specific cellular responses evoked by ezrin inhibition that can be used as a specific pharmacodynamic marker(s), we profiled global gene expression in osteosarcoma cells...

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PMID: 27137931
DOI: 10.1074/jbc.m116.718189

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