Article
The ezrin metastatic phenotype is associated with the initiation of protein translation.
Neoplasia (New York, N.Y.) - 1 Apr 2012
Briggs Joseph W, Ren Ling, Nguyen Rachel, Chakrabarti Kristi, Cassavaugh Jessica, Rahim Said, Bulut Gulay, Zhou Ming, Veenstra Timothy D, Chen Qingrong, Wei Jun S, Khan Javed, Uren Aykut, Khanna Chand
Abstract excerpt
We previously associated the cytoskeleton linker protein, Ezrin, with the metastatic phenotype of pediatric sarcomas, including osteosarcoma and rhabdomyosarcoma. These studies have suggested that Ezrin contributes to the survival of cancer cells after their arrival at secondary metastatic locations. To better understand this role in metastasis, we undertook two noncandidate analyses of Ezrin function including a...
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