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Article

iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy.

Redox biology - 1 Jun 2025

Fan Hangping, Yang Zongkuai, Ying Hangying, Zhao Jiuxiao, Wang Xiaochen, Gong Junhao, Li Lingying, Liu Xujie, Gong Tingyu, Ke Qing, Zhuang Lenan, Liang Ping

Abstract excerpt

LMNA mutation related Emery-Dreifuss muscular dystrophy (LMNA-related EDMD), is a rare genetic disorder often involving life-threatening cardiac complications. However, the molecular links between LMNA mutations and their related EDMD cardiac phenotypes have remained unclear. Here, using EDMD patient-specific and genome-edited induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs), we link the LMNA L204P...

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Topics

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Share to Induced Pluripotent Stem Cells
Share to Janus Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lamin Type A

Share to Muscular Dystrophy, Emery-Dreifuss

Share to Myocytes, Cardiac

Share to Signal Transduction

Share to STAT3 Transcription Factor

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Source

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Identifiers

PMID: 40286437
DOI: 10.1016/j.redox.2025.103638
PMCID: PMC12059692

Genes

LMNA
JAK2
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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